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Off-Label Drug Prescribing: A Common and Controversial Practice A study on off-label drug prescribing done in 2006 found that an estimated 21 percent of all medications prescribed in the United States are done so for off-label usage. The following are medications commonly prescribed for off-label use. Metformin. Metformin is a first-defense drug used to treat high blood sugar and type 2 diabetes. A common ... Off Label Uses For Metformin | DiabetesTalk.Net What follows is a guide tooff label use for Metformin for life extension or longevity enhancement. Metformin isa pharmaceutical drug used to treat type II diabetes, however in a series of studies it has been shown to improve longevity. And while the FDA has not yet approved its use as a therapeutic drug for longevity, it could actually happen. Why Metformin Isn't the Anti-Aging Miracle You Might Think It Is Metformin acts on your mitochondria, the power plants of your cells, as well as AMPK, an enzyme that tells your ...